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ea0037gp.10.03 | Calcium, Vitamin D and Bone | ECE2015

Local administration of non-diabetic MSCs to diabetic femoral fractures enhances callus remodelling and deposition of reparative bone

Watson Luke , Chen Xi Zhe , Ryan Aideen , Loftus Paul , McDonnell Patrick , O'Brien Timothy , Coleman Cynthia

Fractures in diabetic patients are slower to heal and have an increased risk for developing malunion as compared to non-diabetic individuals. Given the known deficiencies in diabetic progenitor cell number and differentiation capacity, it is reasonable to hypothesise the aetiology of diabetic fracture malunion is dysregulated progenitor function. Therefore, we investigated the therapeutic efficacy of locally administered non-diabetic human bone marrow derived mesenchymal stem ...

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Endocrine Abstracts

Local administration of non-diabetic MSCs to diabetic femoral fractures enhances callus remodelling and deposition of reparative bone

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